Stress Degradation Studies of Macrolide Antibiotics “Roxithromycin, Tilmicosin and Tylosin” by Using HPLC

Stress degradation studies control the behavior and impurities of drugs under various stress conditions. The present research is related to all degradation studies including acidic, alkaline, thermal and photo stability on the drug substance according to International Conference on Harmonization ICH guidelines. In this study, the degradation profiles of macrolide antibiotics “roxithromycin ROX , tilmicosin TIL and tylosin TYL ” under varied stress conditions were investigated. The behavior of these drugs under hydrolytic, oxidative, thermal and photolytic conditions were determined by high performance liquid chromatography HPLC